The Tampa Bay Rays struck first in the top of the second inning when José Caballero hit an RBI single to center field, notching the first run of the night. In the top of the fourth inning, Richie Palacios extended the Rays lead with a 2-run home run. The Ray led 3–0.
The White Sox answered strongly in the bottom of the fourth inning. Eloy Jiménez hit a single to left field, followed by a single by Tommy Pham. With players on first and second, Andrew Benintendi launched a 3-run home run to tie the game up 3–3.